Mondal Shovan, Dumur Frédéric, Gigmes Didier, Sibi Mukund P., Bertrand Michèle P., Nechab Malek
Chemical Reviews, 122 5842-5976 (2022)
Mondal Shovan, Dumur Frédéric, Gigmes Didier, Sibi Mukund P., Bertrand Michèle P., Nechab Malek
Chemical Reviews, 122 5842-5976 (2022)
Benefiting from the impressive increase in fundamental knowledge, the last 20 years have shown a continuous burst of new ideas and consequently a plethora of new catalytic methods for enantioselective radical reactions. This review aims to provide a complete survey of progress achieved over this latter period. The first part of this review focuses on the use of chiral organocatalysts, and these include catalysts covalently linked to the substrate and those that interact with the substrate by weaker interactions like hydrogen bonds. The second part of the review is devoted to transition-metal redox catalysis which is organized according to increasing atomic number for the first-row transition metals (Ti, Cr, Fe, Mn, Co, Ni, Cu). Bioinspired manganese- and iron-mediated hydroxylations and oxidations are also discussed. A specific section is dedicated to the reactivity of Ru, Rh, and Ir complexes as Lewis acids with a special focus on complexes chiral at metal. Absorption of photons result in different events such as energy transfer, single-electron transfer, and hydrogen-atom transfer facilitating the formation of radicals. Organocatalysis has been successfully combined with photocatalysts, a reactivity which has opened new pathways enlarging the number of radical precursors available. The merger of photocatalysis with organo- or metalla-photocatalysis has brought novelty and allowed for the discovery of a large number of original transformations. The use of enzyme-catalyzed reactions involving radical intermediates which also largely benefit from visible-light irradiation are included in the review. This review provides a comprehensive inventory of progress in enantioselective radical reactions with a goal of detailing the reaction mechanisms involved in these transformations such that any nonspecialist could find their own creativity to invent yet unknown applications.
Huang Mofei, Xiong Donghai, Pan Jing, Zhang Qi, Wang Yian, Myers Charles R., Johnson Bryon D., Hardy Micael, Kalyanaraman Balaraman, You Ming
Advanced Science, 9 2101267 (2022)
Huang Mofei, Xiong Donghai, Pan Jing, Zhang Qi, Wang Yian, Myers Charles R., Johnson Bryon D., Hardy Micael, Kalyanaraman Balaraman, You Ming
Advanced Science, 9 2101267 (2022)
Abstract Atovaquone, an FDA-approved drug for malaria, is known to inhibit mitochondrial electron transport. A recently synthesized mitochondria-targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in situ vaccination approach, local injection of mitochondria-targeted atovaquone into primary tumors triggered potent T cell immune responses locally and in distant tumor sites. Mitochondria-targeted atovaquone treatment led to significant reductions of both granulocytic myeloid-derived suppressor cells and regulatory T cells in the tumor microenvironment. Mitochondria-targeted atovaquone treatment blocks the expression of genes involved in oxidative phosphorylation and glycolysis in granulocytic-myeloid-derived suppressor cells and regulatory T cells, which may lead to death of granulocytic-myeloid-derived suppressor cells and regulatory T cells. Mitochondria-targeted atovaquone inhibits expression of genes for mitochondrial complex components, oxidative phosphorylation, and glycolysis in both granulocytic-myeloid-derived suppressor cells and regulatory T cells. The resulting decreases in intratumoral granulocytic-myeloid-derived suppressor cells and regulatory T cells could facilitate the observed increase in tumor-infiltrating CD4+ T cells. Mitochondria-targeted atovaquone also improves the anti-tumor activity of PD-1 blockade immunotherapy. The results implicate granulocytic-myeloid-derived suppressor cells and regulatory T cells as novel targets of mitochondria-targeted atovaquone that facilitate its antitumor efficacy.
Yang Xue, Li Chunyang, Giorgi Michel, Siri Didier, Bugaut Xavier, Chatelet Bastien, Gigmes Didier, Yemloul Mehdi, Hornebecq Virginie, Kermagoret Anthony, Brasselet Sophie, Martinez Alexandre, Bardelang David
Angewandte Chemie International Edition, 61 e202214039 (2022)
Yang Xue, Li Chunyang, Giorgi Michel, Siri Didier, Bugaut Xavier, Chatelet Bastien, Gigmes Didier, Yemloul Mehdi, Hornebecq Virginie, Kermagoret Anthony, Brasselet Sophie, Martinez Alexandre, Bardelang David
Angewandte Chemie International Edition, 61 e202214039 (2022)
Abstract Recently, porous organic crystals (POC) based on macrocycles have shown exceptional sorption and separation properties. Yet, the impact of guest presence inside a macrocycle prior to adsorption has not been studied. Here we show that the inclusion of trimethoxybenzyl-azaphosphatrane in the macrocycle cucurbit[8]uril (CB[8]) affords molecular porous host⋅guest crystals (PHGC-1) with radically new properties. Unactivated hydrated PHGC-1 adsorbed iodine spontaneously and selectively at room temperature and atmospheric pressure. The absence of (i) heat for material synthesis, (ii) moisture sensitivity, and (iii) energy-intensive steps for pore activation are attractive attributes for decreasing the energy costs. 1H NMR and DOSY were instrumental for monitoring the H2O/I2 exchange. PHGC-1 crystals are non-centrosymmetric and I2-doped crystals showed markedly different second harmonic generation (SHG), which suggests that iodine doping could be used to modulate the non-linear optical properties of porous organic crystals.
Corentin Pigot, Damien Brunel, Frederic Dumur
MOLECULES, 27 (2022)
Frederic Dumur
EUROPEAN POLYMER JOURNAL, 175 (2022)
Frederic Dumur
EUROPEAN POLYMER JOURNAL, 173 (2022)
Frederic Dumur
EUROPEAN POLYMER JOURNAL, 169 (2022)
Frederic Dumur
EUROPEAN POLYMER JOURNAL, 178 (2022)
Frederic Dumur
EUROPEAN POLYMER JOURNAL, 169 (2022)
Frederic Dumur
EUROPEAN POLYMER JOURNAL, 166 (2022)
Frederic Dumur
EUROPEAN POLYMER JOURNAL, 165 (2022)
Zheng Liu, Frederic Dumur
EUROPEAN POLYMER JOURNAL, 177 (2022)
Hien The Ho, Veronique Montembault, Sagrario Pascual, Laurent Fontaine, Didier Gigmes, Trang N. T. Phan
POLYMER CHEMISTRY, 13 5226-5233 (2022)
Ritam Mansour, Saikat Mukherjee, Max, Jr. Pinheiro, Jennifer A. Noble, Christophe Jouvet, Mario Barbatti
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 24 12346-12353 (2022)
Mariana T. do Casal, Josene M. Toldo, Felix Plasser, Mario Barbatti
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 24 23279-23288 (2022)
Elizete Ventura, Silmar Andrade do Monte, Mariana T. do Casal, Max, Jr. Pinheiro, Josene Maria Toldo, Mario Barbatti
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 24 9403-9410 (2022)
Mario Barbatti
JOURNAL OF CHEMICAL PHYSICS, 156 (2022)
Saikat Mukherjee, Max Pinheiro Jr, Baptiste Demoulin, Mario Barbatti
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 380 (2022)
Ritam Mansour, Josene M. Toldo, Mario Barbatti
JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 13 6194-6199 (2022)
Dao Le, Amelie Frison, Yasmine Masmoudi, Abir Bouledjouidja, Pierre Thureau, Giulia Mollica, Elisabeth Badens, Fabio Ziarelli, Stephane Viel
MAGNETIC RESONANCE IN CHEMISTRY, 60 1171-1177 (2022)
Cedric Spitz, Morgane Bertrand, Vincent Remusat, Thierry Terme, Patrice Vanelle
JOURNAL OF ORGANIC CHEMISTRY, 87 4483-4488 (2022)
Junteng Wu, Nicolas Brun, Juan Miguel Gonzalez-Sanchez, Badr R'Mili, Brice Temime Roussel, Sylvain Ravier, Jean-Louis Clement, Anne Monod
ATMOSPHERIC MEASUREMENT TECHNIQUES, 15 3859-3874 (2022)
Marc Alias-Rodriguez, Miquel Huix-Rotllant, Coen de Graaf
FARADAY DISCUSSIONS, 237 93-107 (2022)
Aurelien Vebr, Magali Dallegre, Laurent Autissier, Charlotte Drappier, Karel Le Jeune, Didier Gigmes, Anthony Kermagoret
POLYMER CHEMISTRY, 13 3275-3283 (2022)
Corentin Pigot, Sebastien Peralta, Thanh-Tuan Bui, Malek Nechab, Frederic Dumur
DYES AND PIGMENTS, 202 (2022)
Eric Besson, Aurelien Vebr, Fabio Ziarelli, Emily Bloch, Guillaume Gerbaud, Severine Queyroy, Pierre Thureau, Stephane Viel, Stephane Gastaldi
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 24 25279-25286 (2022)
Sebastien Redon, Vincent Remusat, Patrice Vanelle
SYNLETT, 33 483-487 (2022)
Yijun Zhang, Hong Chen, Loic Vidal, Gautier Schrodj, Fabrice Morlet-Savary, Frederic Dumur, Angelique Simon-Masseron, Jacques Lalevee
ADVANCED MATERIALS TECHNOLOGIES, 7 (2022)
S. Liu, N. Giacoletto, B. Graff, F. Morlet-Savary, M. Nechab, P. Xiao, F. Dumur, J. Lalevee
MATERIALS TODAY CHEMISTRY, 26 (2022)
Soumya Mukherjee, Saikat Hazra, Sandip Ghosh, Saikat Mukherjee, Satrajit Adhikari
CHEMICAL PHYSICS, 560 (2022)