Institute of Radical
Research at the Institute of Radical Chemistry focuses on compounds carrying single electrons. We master their structure through synthesis, characterization and simulations to access a broad range of applications from advanced materials to therapeutic uses.
8 research teams working at the interfaces of radical chemistry, organic synthesis, simulations, materials or even biology.
Welcome to Dr Zoltan Kovacs from the Advanced Imaging Research Center UT Southwestern, Dallas
The ICR is pleased to welcome until the 11th of july Dr Zoltan Kovacs (Advanced Imaging Research Center UT Southwestern, Dallas (TX, USA)).
His primary research interests include the synthesis and application of hyperpolarized metal complexes and 13 carbon-labeled metabolic intermediates, and the design of new paraCEST, T1, and radiopharmaceutical imaging agents. (Local contact: Olivier Ouari)
The Institute of Radical Chemistry celebrates its 10th anniversary !
On May 4 2022, the ICR celebrated its 10th anniversary organizing an international symposium with prestigious speakers.
We had the honor of receiving: Prof. K. Matyjaszewski, Dr. J-F. Lutz, Prof. J. Lalevée, Prof. L. Emsley, Prof. D. Bailey and Prof. M. Olivucci.
A NMR DNP equipment in Marseille!
The Dynamic Nuclear Polarization technique allow to overcome the low sensitivity of the NMR technique thanks to the principle of the transfer of spin polarization from electrons to nuclei.
Find this new equipment at the Spectropole of the Federation Sciences Chimiques Marseille
Prevention of tumor growth and dissemination by in situ vaccination with mitochondria-targeted atovaquone
Advanced Science, 2022, e2101267
Atovaquone, an FDA-approved drug for malaria, is known to inhibit mitochondrial electron transport. In this study, researchers from the Medical College of Wisconsin, the Center for Cancer Prevention and the SREP team showed that the synthesized mitochondria-targeted atovaquone (Mito-ATO) increased mitochondrial uptake in both cancer cells and immunosuppressive cells in the TIME. Local intratumoral injection of Mito-ATO into primary tumors triggered potent T cell immune responses locally and in distant tumor sites.
Enantioselective Radical Reactions Using Chiral Catalysts
Chemical Reviews, 2022, on line
Enantioselective radical reactions have long been considered as rather limited for efficient stereocontrol, but recent developments have upturned this common belief. A spectacular advance in the development of catalyzed enantioselective radical reactions has been seen. Important innovations in the use of different chiral organocatalysts and transition-metal catalysts have been the major contributors in the development of enantioselective radical reactions.
Ultrafast Intersystem Crossing in Xanthone from Wavepacket Dynamics
J. Am. Chem. Soc. 2021, Accepted article
By means of quantum dynamic simulations, researchers of the CT team and the ICREA have established the photochemical mechanism of the atypical fast singlet-triplet transition in the excited state of Xanthone. They demonstrated the barrierless access to electronic state intersections. These intersections are close to minimum energy structures, allowing for such efficient non-radiative transition between singlets and triplets.
Monitoring Crystallization Processes in Confined Porous Materials by Dynamic Nuclear Polarization Solid-State Nuclear Magnetic Resonance
Journal of the American Chemical Society, 2021, 143, 6095−6103
Researchers from the SACS and CMO teams showed that solid-state NMR, combined with dynamic nuclear polarization (DNP), enables efficient detection of metastable, transient species formed at the early stages of crystallization processes occurring in pure water under nanoconfinement. The approach relies on a new class of polarizing agents composed of mesoporous silica materials with TEMPO radicals embedded in the walls of the material, developed at the ICR.
Focus on the project of Juan Miguel Gonzalez Sanchez, PhD student at the LCE and the CROPS team
In the framework of the DOC2AMU program , Juan Miguel Gonzalez Sanchez of the Laboratoire de Chimie de l’Environnement (LCE) and the CROPS team is presenting his PhD work on “Multiphase reactivity of polyfunctional organic nitrates in the atmosphere : MULTI-NITRATES” in collaboration with the AtmoSud organisation.
Project supported by the European Commission, the Sud region (Provence-Alpes-Côte d’Azur), the CNRS and the A*Midex foundation of Aix Marseille University