Institute of Radical
Research at the Institute of Radical Chemistry focuses on compounds carrying single electrons. We master their structure through synthesis, characterization and simulations to access a broad range of applications from advanced materials to therapeutic uses.
8 research teams working at the interfaces of radical chemistry, organic synthesis, simulations, materials or even biology.
Congratulation Maxence ! Regional final of the "My Thesis in 180 seconds" contest
Congratulations to Maxence Holzritter who well defended the ICR colors at the regional final of the "My Thesis in 180 seconds" contest
A real Prince Charming!
Welcome on the new website of the ICR !
The media team of the Institute of Radical Chemistry is proud to present its new website.
Good Navigation !
PEPPERSchool Peptide and Protein Engineering: from Concepts to Biotechnological Applications
The second edition of the international PEPPERSchool (Peptide and Protein Engineering: from Concepts to Biotechnological Applications) will take place by videoconferences from March 15 to18, 2021. This interactive school will gather international experts from the field of peptide/protein chemistry as well as molecular biology methodologies.
A new NMR DNP equipment in Marseille!
The Dynamic Nuclear Polarization technique allow to overcome the low sensitivity of the NMR technique thanks to the principle of the transfer of spin polarization from electrons to nuclei.
Find this new equipment at the Spectropole of the Federation Sciences Chimiques Marseille
37e French days of Mass Spectrometry #SFSM2020
Rescheduled in 2022.
In the mean time, the SFSM looks forward to seeing you at the joint congress SMMAP2021, organized in Nantes, 13-16 September 2021 (https://www.smmap2021.fr/).
In the framework of the DOC2AMU program , Xue Yang of the SREP team is presenting her PhD work on “Functionalized-Cucurbit[n]urils: Advanced Drug Carriers” in collaboration with the Institute of NeuroPhysiopathology and the biotechnology company Vect-Horus.
Project supported by the European Commission, the Sud region (Provence-Alpes-Côte d’Azur), the CNRS and the A*Midex foundation of Aix Marseille University
Guest exchange by a partial energy ratchet in water
Angew. Chem. Int. Ed. 2021, 60, 6617-6623
Landmark advances have recently allowed to mimic some mechanical aspects of biological molecular machines, but all the reported systems work in organic solvents. Researchers from the SREP, SACS, CROPS teams and University of Macau (Institute of Chinese Medical Sciences) have now described a partial energy ratchet working in water, suggesting that the macrocycles cucurbiturils could become prime components for the construction of advanced molecular machines.
Precise alkoxyamine‐design enables automated tandem mass spectrometry sequencing of digital poly(phosphodiester)s
Angew. Chem. Int. Ed. 2020, asap
The CROPS and SACS teams, in collaboration with the group of Dr. Jean‐François Lutz of the Institut Charles Sadron, had already taken a major step towards reliable reading of information coded in the sequence of long poly(phosphodiester)s by manual MS/MS decoding. Now, new alkoxyamines have been designed to enable automated MS/MS sequencing. The automated decoding of these polymers can be achieved using the MS‐DECODER software, which interprets the fragmentation data prior to align the digital sequences in their original order based.
Structural Analysis of an Antigen Chemically-Coupled on Virus‐Like Particles in Vaccine Formulation
Angew. Chem. Int. Ed. 2021, 10.1002/anie.202013189
The SREP team, in collaboration with the groups of Dr. G. Pintacuda, Prof. K. Tars, and Prof. K. Jaudzems, showed that magic‐angle spinning (MAS) solid‐state NMR can be used to assess the structure of the influenza virus hemagglutinin stalk long alpha helix antigen, both in its free, unformulated form and once chemically coupled to the surface of large virus‐like particles (VLPs). This work demonstrates that high‐sensitivity MAS NMR is ripe to play a major role in vaccine design, formulation studies and manufacturing process development.
Damage and Repair in Informational Poly(N‐substituted urethane)s
Angew. Chem. Int. Ed. 2020, 59, 20390-20393
Laurence Charles of the SACS team, in collaboration with the group of Dr. Jean‐François Lutz of the Institut Charles Sadron, studied the degradation and repair of uniform sequence‐defined poly(N‐substituted urethane)s . Their findings open up interesting new avenues for chain‐healing and sequence editing.