Institute of Radical
Research at the Institute of Radical Chemistry focuses on compounds carrying single electrons. We master their structure through synthesis, characterization and simulations to access a broad range of applications from advanced materials to therapeutic uses.
8 research teams working at the interfaces of radical chemistry, organic synthesis, simulations, materials or even biology.
Donation from the ROGER PELLENC FOUNDATION
The ICR thanks the ROGER PELLENC FOUNDATION for its support for the development of laboratory research. The objective of this foundation is the development of French scientific knowledge in the field of renewable energies and in particular new generation batteries.
The Institute of Radical Chemistry celebrates its 10th anniversary !
On May 4 2022, the ICR celebrated its 10th anniversary organizing an international symposium with prestigious speakers.
We had the honor of receiving: Prof. K. Matyjaszewski, Dr. J-F. Lutz, Prof. J. Lalevée, Prof. L. Emsley, Prof. D. Bailey and Prof. M. Olivucci.
A NMR DNP equipment in Marseille!
The Dynamic Nuclear Polarization technique allow to overcome the low sensitivity of the NMR technique thanks to the principle of the transfer of spin polarization from electrons to nuclei.
Find this new equipment at the Spectropole of the Federation Sciences Chimiques Marseille
Energy-Efficient Iodine Uptake by a Molecular Host•Guest Crystal
Angew. Chem. Int. Ed., 2022
of iodine molecules is crucial when corresponding radioactive
isotopes, implied in thyroid cancer, are released in nuclear power plants, or
after nuclear accidents. The discovered material, made of molecular crystals
formed by the stacking of Host-Guest complexes, possesses channels perfectly
suited for iodine molecules even if these are preliminary filled by water
Prevention of tumor growth and dissemination by in situ vaccination with mitochondria-targeted atovaquone
Advanced Science, 2022, e2101267
Atovaquone, an FDA-approved drug for malaria, is known to inhibit mitochondrial electron transport. In this study, researchers from the Medical College of Wisconsin, the Center for Cancer Prevention and the SREP team showed that the synthesized mitochondria-targeted atovaquone (Mito-ATO) increased mitochondrial uptake in both cancer cells and immunosuppressive cells in the TIME. Local intratumoral injection of Mito-ATO into primary tumors triggered potent T cell immune responses locally and in distant tumor sites.
Enantioselective Radical Reactions Using Chiral Catalysts
Chemical Reviews, 2022, on line
Enantioselective radical reactions have long been considered as rather limited for efficient stereocontrol, but recent developments have upturned this common belief. A spectacular advance in the development of catalyzed enantioselective radical reactions has been seen. Important innovations in the use of different chiral organocatalysts and transition-metal catalysts have been the major contributors in the development of enantioselective radical reactions.
Focus on the project of Juan Miguel Gonzalez Sanchez, PhD student at the LCE and the CROPS team
In the framework of the DOC2AMU program , Juan Miguel Gonzalez Sanchez of the Laboratoire de Chimie de l’Environnement (LCE) and the CROPS team is presenting his PhD work on “Multiphase reactivity of polyfunctional organic nitrates in the atmosphere : MULTI-NITRATES” in collaboration with the AtmoSud organisation.
Project supported by the European Commission, the Sud region (Provence-Alpes-Côte d’Azur), the CNRS and the A*Midex foundation of Aix Marseille University