Associate Professor

PCR team

04 91 83 56 57

nicolas.primas@univ-amu.fr

Main activities:

In order to develop new antifective agents, our work focuses on the synthesis of new heterocyclic molecules endowed with an antiparasitic activity mainly against neglected tropical diseases : malaria, leishmaniasis, African and American Human trypanosomiasis. These works aim at identifying the molecular action mechanisms to find new pathways and therefore circumvent resistance phenomena. The physicochemical, properties, structure-activity relationships, and pharmacokinetic parameters of these compounds are determined according to a Hit-to-Lead approach to realize in vivo tests on infected animal models.

 Keywords:

Organic synthesis, heterocyclic chemistry, biological activity, molecular action mechanism, physicochemical properties, pharmacokinetic properties, Plasmodium, Leishmania, Trypanosoma

Teaching:

  • CM Chemical design of medicines DFGSP2 Pharmacy
  • TP pharmacochemistry DFGSP2 Pharmacy
  • CM Green chemistry DFGSP3 Pharmacy
  • TP Green chemistry DFGSP3 Pharmacy
  • CM Public healthcare – Hydrology DFASP1 Pharmacy TP Public Healthcare – Hydrology DFASP1 Pharmacy

https://orcid.org/0000-0002-6713-6039