In line with their work on the development of more efficient agents, researchers from the SREP, in collaboration with the group of Lyndon Emsley (EPFL), Anne Lesage of the Centre de RMN à très hauts champs (ENS Lyon), the CERM of Florence, and the ETH EPR spectroscopy group, have identified a new key parameter for the rational design of polarizing agents for the DNP MAS ssNMR technique. A tremendous amount of work in synthesis, EPR and NMR have shown that the local geometry can drive to a jump in the DNP efficiency of nitroxides by a factor of 10 !