Publication authors: Patrice Vanelle

Heterocyclic Naphthoquinones Derivatives for Use in the Treatment of Cancers Including Cushing Disease

Pd-catalyzed C-C and C-N cross-coupling reactions in 2-aminothieno[3,2-d]pyrimidin-4(3H)-one series for antiplasmodial pharmacomodulation

Synthesis and Anti-Trypanosoma cruzi Biological Evaluation of Novel 2-Nitropyrrole Derivatives

4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives

Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore

Novel Synthesis of Pyrido[2,3-b ]quinoxaline-3-carboxylate Derivatives via One-Pot Buchwald Amination-Cyclization

Iodine/Sulfinates: Rapid and Convenient Thiolation of Imidazo Heterocycles without Additives

Paediatric capsule compounding in hospital practices: by weight or by volume?

Real-world efficacy and safety of pembrolizumab in patients with non-small cell lung cancer: a retrospective observational study

Synthesis of 3-Benzylphthalide Derivatives by Using a TDAE Strategy

Original TDAE reactivity in benzoxa- and benzothiazolone series

TDAE-assisted synthesis of new imidazo[2,1-b]thiazole derivatives as anti-infectious agents

Original quinazoline derivatives displaying antiplasmodial properties

Efficient one-pot double Buchwald-Hartwig coupling reaction on 5-phenyl-4-phenylsulfonyl-2,3-dihydrofuran derivatives

Tandem synthesis and in vitro antiplasmodial evaluation of new naphtho[2,1-d] thiazole derivatives

TDAE Strategy in the Benzoxazolone Series: Synthesis and Reactivity of a New Benzoxazolinonic Anion

Synthesis of New 2,4-Disubstituted 2,3-Dihydrobenzo[g]indol-5-ones by an S(RN)1 Strategy

Synthesis and Anti-Platelet Activity of Thiosulfonate Derivatives Containing a Quinone Moiety

Original synthesis of benzo[f]indole-4,9-dione derivatives using TDAE strategy

Looking for new antileishmanial derivatives in 8-nitroquinolin-2(1H)-one series

Efficient Access to 2,6,8-Trisubstituted 4-Aminoquinazolines through Microwave-Assisted One-Pot Chemoselective Tris-Suzuki-Miyaura or SNAr/Bis-Suzuki-Miyaura Reactions in Water

Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium

Cross-Coupling Synthesis of Methylallyl Alkenes: Scope Extension and Mechanistic Study

Antileishmanial pharmacomodulation in 8-nitroquinolin-2(1H)-one series

An Efficient Method for the Synthesis of 2-Methylallyl Alkenes by Cross-Coupling Reactions

VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection

Studies toward the oxidative and reductive activation of C-S bonds in 2 '-S-aryl-2 '-thiouridine derivatives

Mild and Metal-Free Regioselective 1,2-Addition of Carbon Nucleophiles to alpha,beta-Unsaturated Imines

Using the Sonogashira Reaction for Preparing a New Fragment Library based on the 3-alkynylimidazo[1,2-alpha] pyridine Scaffold

Synthesis and evaluation of in vitro antiproliferative activity of new ethyl 3-(arylethynyl)quinoxaline-2-carboxylate and pyrido[4,3-b] quinoxalin-1(2H)-one derivatives

Polymerization Initiated by Organic Electron Donors

Rapid and Convenient Synthesis of Original 5-Substituted Quinolino[3,4-b]quinoxalin-6(5H)-ones under Eco-Friendly Conditions

Mn(OAc)(3) catalyzed intermolecular oxidative peroxycyclization of naphthoquinone

Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold

Efficient Access to Original 6-Substituted 5-Nitro-2,3-dihydroimidazo-[2,1-b]oxazoles

Metal-Free Regiodivergent Addition of Carbon Nucleophiles to alpha,beta-Unsaturated Electrophiles

Easy and efficient selenocyanation of imidazoheterocycles using triselenodicyanide

An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities

Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: A combined computational and experimental study

Synthesis and in vitro evaluation of new 5-substituted 6-nitroimidazooxazoles as antikinetoplastid agents

Quinoxaline Derivatives as Antiviral Agents: A Systematic Review

Synthesis, In Vitro Antiproliferative Activity, and In Silico Evaluation of Novel Oxiranyl-Quinoxaline Derivatives

Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy

Dichloro4-(4-chlorophenoxy)phthalazin-1-yl methylphosphonic dichloride

Green Synthesis of Diaryl Selenides from Arylboronic Acids and Arylseleninic Acids

Addition of Benzyl Halides to Aldehydes and Imines Using Photoactivated TDAE: Access to 3,4-Dihydroisocoumarins, 1,2-Diarylethanols, and 1,2-Diarylcarbamates under Metal-Free Conditions

Targeted Based Therapies in Metastatic Breast Cancer: Future Evolution

Unexpected palladium catalyzed O-arylation occurring in 4-(4-fluoro-3-nitrophenyl)-1,2-dimethyl-5-nitro-1H-imidazole series

Mild and Metal-Free Diastereoselective Synthesis of N-tert-Butanesulfinylamines by Using Tetrakis(dimethylamino)ethylene

Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines

Spectral investigations on the influence of silver nanoparticles on the fluorescence quenching of 1,4-dimethoxy-2,3-dibromomethylanthracene-9,10-dione

Exploring the Synthesis and the Reactivity of 4-[4-(Chloromethyl) styryl]-1,2-dimethyl-5-nitro-1H-imidazole in TDAE Strategy

A new DMAP-catalyzed and microwave-assisted approach for introducing heteroarylamino substituents at position-4 of the quinazoline ring

A novel benzonitrile analogue inhibits rhinovirus replication

Novel Synthesis of 5-Substituted 5H-Benzo[b] carbazole-6,11-diones via Double Buchwald-Hartwig Reaction

Synthesis of Novel Highly Functionalized 4-Thiazolidinone Derivatives from 4-Phenyl-3-thiosemicarbazones

One-pot preparation of 2-(alkyl)arylbenzoselenazoles from the corresponding N-(acetyl)benzoyl-2-iodoanilines via a microwave-assisted methodology

Synthesis and in vitro evaluation of 4-trichloromethylpyrrolo[1,2-a]quinoxalines as new antiplasmodial agents

First single electron transfer reaction on propargylic chloride in 5-nitroimidazole series

An expeditious method for the selective cyclotrimerization of isocyanates initiated by TDAE

New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation

mediEVAL: a New Evaluating Tool for the Medication-use System

Designing New 5-Nitroimidazoles: Towards Safer Anti-infectious Agents

Synthesis, biological activity and structure-activity relationship of 4,5-dimethoxybenzene derivatives inhibitor of rhinovirus 14 infection

One-Pot Chemoselective Synthesis of 2,4,6,8-Tetrasubstituted Quinazolines via Microwave-Assisted Consecutive Bis-SNAr/Bis-Suzuki-Miyaura Cross-Coupling Reactions

Rapid and efficient synthesis of 2-substituted-tetrahydropyrido[3,4-b]quinoxalines using TDAE strategy

Synthesis of 4-Alkynyl-1,2-dimethyl-5nitro-1H-imidazoles via Microwave-Assisted Sonogashira Cross-Coupling Reactions

Organic Electron Donors as Powerful Single-Electron Reducing Agents in Organic Synthesis

TDAE Strategy for the Synthesis of 2,3-Diaryl N-Tosylaziridines

Targeting the human parasite Leishmania donovani: Discovery of a new promising anti-infectious pharmacophore in 3-nitroimidazo[1,2-a]pyridine series

Efficacy and Toxicity of Factor Xa Inhibitors

Diastereoselective Synthesis of N-tert-Butanesulfinylamines through Addition of p-Nitrobenzyl Chloride to N-tert-Butanesulfinimines Using a TDAE Strategy

Amyotrophic Lateral Sclerosis: Update on Etiological Treatment

Efficacy and Future of the Aerosoltherapy in the Treatment of Cystic Fibrosis Patients Infected by Pseudomonas aeruginosa

Access to original spirocyclic derivatives via inter- or intramolecular reaction mediated by manganese(III) acetate

Sonogashira cross-coupling reaction in 4-chloro-2-trichloromethylquinazoline series is possible despite a side dimerization reaction

Original TDAE Strategy Using Propargylic Chloride: Rapid Access to 1,4-Diarylbut-3-ynol Derivatives

Manganese(III) Acetate-mediated Oxidative Cyclization of alpha-Methylstyrene and trans-Stilbene with beta-Ketosulfones

Preparation and antiprotozoal evaluation of promising beta-carboline alkaloids

A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro

Synthesis and Promising in Vitro Antiproliferative Activity of Sulfones of a 5-Nitrothiazole Series

First Long-Distance S(RN)1 on a propargylic chloride

Safety Review: Squalene and Thimerosal in Vaccines

One-Pot Chemoselective Bis(Suzuki-Miyaura Cross-Coupling): Efficient Access to 3,9-Bis[(hetero)aryl]-4H-pyrido[1,2-a]pyrimidin-4-one Derivatives Under Microwave Irradiation

Targeting the human malaria parasite Plasmodium falciparum: In vitro identification of a new antiplasmodial hit in 4-phenoxy-2-trichloromethylquinazoline series

News on Infantile Hemangioma Therapy by Beta-blocker

Long distance-S(RN)1 in nitroimidazole series favored by temperature

Discovery of a new antileishmanial hit in 8-nitroquinoline series

A New Synthetic Route to Original Sulfonamide Derivatives in 2-Trichloromethylquinazoline Series: A Structure-Activity Relationship Study of Antiplasmodial Activity

New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate

Synthesis and evaluation of monoamidoxime derivatives: Toward new antileishmanial compounds

Organic Glues or Fibrin Glues from Pooled Plasma: Efficacy, Safety and Potential as Scaffold Delivery Systems

New pyrazole derivatives of potential biological activity

Use of intravenous immunoglobulins in clinical practice: data from three French university hospitals

Efficient and Original Microwave-Assisted Suzuki-Miyaura Cross-Coupling Reaction in the 4H-Pyrido[1,2-a]pyrimidin-4-one Series

First SNAr reaction using TDAE-initiated carbanions in quinazoline series

4-Thiophenoxy-2-trichloromethyquinazolines display in vitro selective antiplasmodial activity against the human malaria parasite Plasmodium falciparum

Pyridine-Based Heterocycles. Synthesis of New Pyrido [4 ',3 ':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles

High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach

Original synthesis of 2-substituted-4,11-dimethoxy-1-(phenylsulfonyl)-2,3-dihydro-1H-naphtho[2 ,3-f]indole-5,10-diones using TDAE and Cu-catalyzed reaction strategy